Dr Martin Blackledge
Martin Blackledge studied physics at the University of Manchester, and received his D.Phil with Professor George Radda at the University of Oxford in 1987. During his post-doc in the group of Professor Richard Ernst in Zürich, he started working on conformational dynamics of biomolecules, in particular using rotating frame relaxation and multi-conformational exchange NMR. Since 1992 he has worked for the CEA at the Institute de Biologie Structurale in Grenoble, France. He directs the Protein Dynamics and Flexibility by NMR group, using NMR spectroscopy to study how protein dynamics control biomolecular function. His recent research efforts have described the conformational dynamics of proteins of many flavours, from folded to intrinsically disordered proteins, via large-scale domain dynamics. His group uses spin relaxation, exchange techniques, ensemble-based analyses and MD to understand the role of protein flexibility in biological processes such as viral replication, neurodegenerative disease, and cellular signaling.